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In the realm of global health research, the National Institute for Medical Research (NIMR) in Tanzania has emerged as a central player, spearheading international collaborations that promise groundbreaking advancements. At the forefront of these efforts is the visionary leadership of NIMR’s Director General, Prof Said S. Aboud, who is navigating the institute towards extended global partnerships and scientific excellence. The recent discussions between NIMR and French Ambassador to Tanzania and Permanent delegate to UNESCO, Hon. Ali J. Mwadini, underscore the pivotal role that NIMR plays in fostering international research collaborations. The engagement, which also included representatives from institutions such as NTLP, KIDH, and Amref, reflects a concerted effort to leverage collective expertise for the betterment of global health. Director General Prof Said S. Aboud, a stalwart in the field of medical research, is leading the charge to position NIMR as a hub for international collaboration. His commitment to advancing health research is evident in the institute’s strategic approach to engage in discussions that explore possibilities for extended partnerships. Prof Aboud’s leadership not only aligns with the broader goals of NIMR but also underscores the institute’s dedication to making significant contributions to the global scientific community. The focus of the talks centered around the potential for extended international research partnerships, with NIMR taking a leading role in these discussions. As the directorate overseeing health research in Tanzania, NIMR holds a unique position to drive impactful scientific collaboration. The involvement of Prof Aboud in these discussions signifies not only his personal dedication but also the institute’s collective commitment to playing a central role in addressing global health challenges. Moreover, the inclusion of diasporas in these discussions adds a dynamic dimension to NIMR’s approach to international collaboration. Prof Aboud’s recognition of the value that diasporas bring to the table highlights a forward-thinking strategy that seeks to harness diverse perspectives and expertise for comprehensive and innovative health research solutions. The hashtags #HealthResearch and #ScientificCollaboration, featured in the tweet, succinctly capture the essence of NIMR’s mission. By placing health research at the forefront and emphasizing the importance of scientific collaboration, NIMR and Prof Said S. Aboud are signaling a commitment to advancing knowledge and contributing to the global scientific discourse. In conclusion, NIMR, under the astute leadership of Director General Prof Said S. Aboud, stands as a beacon of progress in global health research. The recent discussions with French stakeholders mark a significant stride towards international collaboration, positioning NIMR as a key player in the global pursuit of scientific excellence and improved health outcomes. As the institute continues to lead the charge, the world watches with anticipation for the transformative impact that NIMR’s contributions will undoubtedly have on the future of global health research.

Introduction:In a groundbreaking collaboration, the National Institute for Medical Research (NIMR) and the Tanzania Human Genetics Organization (THGO) convened the National Stakeholders’ Meeting on Human Genomics. The meeting held on November 15, 2023, at the University of Dar es Salaam Conference Hall. The event aimed to promote the use of human genomic testing in the diagnosis of various diseases across the country.   Distinguished Opening:The conference commenced with an inaugural address by the Minister of Health for the Revolutionary Government of Zanzibar, Hon. Nassor Mazrui. He commended NIMR and THGO for their concerted efforts in bringing together stakeholders from diverse institutions and organizations. The minister acknowledged the significance of the collaborative initiative and its potential impact on shaping the future of human genomic research in Tanzania. Conference Objectives:The objective of the meeting is to bring together Human Genetics Stakeholders from both mainland Tanzania and the Island of Zanzibar to develop the National Agenda for human genetics in Tanzania for 2025-2035. This meeting symbolizes a significant milestone in Tanzania’s journey towards harnessing the potential of human genetics knowledge to improve health outcomes by unlocking the transformative power of the field in research and innovation. Key Highlights:During the conference, NIMR researchers presented compelling insights into the correlation between non-communicable diseases and human genetics. Their presentations underscored the critical role that genomic information can play in understanding, preventing, and treating diseases that pose a significant health burden in Tanzania. Conclusion:The National Stakeholders’ Meeting on Human Genomics marks a pivotal moment in Tanzania’s journey towards leveraging genomic information for healthcare advancements. NIMR and THGO, through their collaborative efforts, have set the stage for a decade of transformative research and innovation, with the ultimate goal of enhancing the health and well-being of the Tanzanian population.

Dr. Christina Kisha Manyama MD, Clinical trial Specialist and the National Principal Investigator of the Sutezolid Dose finding and Combination evaluation (SUDOCU trial) from @NIMRMbeya presenting findings of the @EDCTP funded @PanACEA_II SUDOCU trial whereby sutezolid with the backbone of bedaquiline+delamanid+moxifloxacin was well tolerated when given over 12 weeks and improved the treatment efficacy. Noticeably, the SUDOCU trial recruited participants from sites in Tanzania @NIMR Mbeya, @IHI, @Kibong`oto @KCRITanzania and South Africa @Auruminstitute. The trial was presented in a TB Science Session @UnionConference in Paris France titled “TB within the Global AMR fight: Prevention drug resistance” #EndTB2030 #GlobalHealth #ResearchMatters #UnionConference #SUDOCUTrial #AMRFight

Empowering Safety: NIMR’s Comprehensive Fire Safety Training for a Secure Workplace and Community In a proactive initiative to enhance the safety and well-being of its employees, the National Institute for Medical Research (NIMR) organized a comprehensive training session on fire safety in collaboration with the Dar es Salaam Fire Brigade. The event, which took place on November 7, 2023, at the NIMR Headquarters in Dar es Salaam, was a crucial step towards ensuring that staff members are well-equipped to handle and mitigate fire emergencies both at work and in their homes. The training encompassed a blend of theoretical insights and practical demonstrations, providing participants with valuable knowledge on various aspects of fire safety. The focus extended beyond the workplace, addressing scenarios that could unfold at home or during travel, emphasizing the importance of a holistic approach to fire prevention and management. Theoretical sessions delved into the science of fire, understanding its behavior, and the different types of fires that may occur in diverse settings. Participants gained insights into the proper usage of fire extinguishers, emergency evacuation procedures, and the significance of early detection systems. Understanding the critical role of quick and efficient responses in the face of a fire emergency, the training underscored the importance of a well-prepared and educated workforce. Practical training sessions were conducted to simulate real-life scenarios, allowing participants to apply their knowledge in a controlled environment. From using fire extinguishers effectively to practicing safe evacuation techniques, employees actively engaged in hands-on activities that reinforced the theoretical principles discussed earlier in the training. The collaboration with the Dar es Salaam Fire Brigade added a valuable dimension to the training, bringing in experts with practical experience in handling diverse fire emergencies. Their insights, shared during interactive sessions, provided NIMR employees with a deeper understanding of the challenges faced by firefighting professionals and the importance of a collaborative approach in ensuring community safety. Beyond workplace-specific scenarios, the training also emphasized the broader societal impact of fire safety awareness. Participants were encouraged to disseminate their newly acquired knowledge within their communities, fostering a culture of safety that extends beyond the confines of the workplace. In conclusion, the fire safety training at NIMR stands as a testament to the institute’s commitment to the well-being of its employees. By investing in comprehensive and practical training programs, NIMR ensures that its workforce is not only educated but also empowered to respond effectively to unforeseen fire emergencies. This initiative reflects the institute’s dedication to creating a safe and secure environment for its employees and contributing to a broader culture of safety within the community.

Collaborative Efforts in Combating Non-Communicable Diseases: NIMR’s Participation in the 2023 Congress The National Institute for Medical Research (NIMR) today, on November 1, 2023, participated in a Non-Communicable Diseases Conference organized in collaboration with Muhimbili University of Health and Allied Sciences and the Ministry of Health. The congress is taking place at the Julius Nyerere International Conference Center in Dar es Salaam. This three-day conference aims to strengthen regional cooperation in policy, research, and innovation for the prevention, monitoring, and control of non-communicable diseases. It is expected to conclude on Friday, November 3, 2023, during which NIMR researchers will present various topics related to these diseases and engage in discussions with experts from various institutions. #Ministry of Health #Better Health #Non-Communicable Diseases#

Leadership Training and Capacity Building at NIMR: Fostering Effective Leadership and Workplace Dynamics The Director General of the National Institute for Human Diseases Research (NIMR), Prof. Said Aboud, presenting participation certificates to Senior Officials of the Institute after their participation in a 3-day leadership training conducted by the Leadership Institute. The training aimed to build the capacity of leaders to enhance their effectiveness in the execution of their daily responsibilities. In addition, various topics were discussed, including job delegation, workplace conflict reduction, workplace relationships, collaboration, work ethics, and public resource management.

Regional NCD Conference in Dar es Salaam with NIMR: Fostering Collaboration and Innovation in Non-Communicable Disease Prevention and Control” The Non-Communicable Diseases (NCD) Conference, held in Dar es Salaam at the Julius Nyerere International Convention Centre, is a significant event that spans three days, running from November 1 to November 3, 2023. The primary objective of this conference is to bolster regional collaboration in the fields of policy development, research, and innovation with a specific focus on the prevention, monitoring, and control of non-communicable diseases. Non-communicable diseases, often referred to as NCDs, encompass a broad range of health conditions such as cardiovascular diseases, diabetes, cancer, and chronic respiratory diseases. These diseases have become a growing public health concern, not only in Tanzania but also globally. The conference brings together experts, researchers, healthcare professionals, and policymakers from various institutions to collectively address this pressing issue. Key highlights of the Non-Communicable Diseases Conference include: 1. **Multidisciplinary Insights:** The conference serves as a platform for experts from diverse backgrounds to share their knowledge, research findings, and practical experiences related to NCDs. This multidisciplinary approach is essential in understanding the complex nature of these diseases and developing effective strategies for their prevention and management. 2. **Policy Development:** Policymakers and government officials participate in the conference to engage in discussions and workshops focused on developing policies that address NCDs. Effective policies play a crucial role in regulating healthcare systems and promoting public health. 3. **Innovative Solutions:** With a strong emphasis on innovation, the conference encourages the exploration of creative solutions to combat NCDs. These solutions may range from innovative medical interventions to novel public health campaigns. 4. **Regional Collaboration:** Collaboration is a key theme, as NCDs are not limited by borders. The conference provides an opportunity for regional cooperation, enabling attendees to learn from each other’s successes and challenges in dealing with these diseases. The conference’s conclusion on November 3, 2023, is anticipated to result in a wealth of knowledge and a roadmap for addressing non-communicable diseases in Tanzania and the broader East African region. The insights gained during this event are expected to drive policies and actions aimed at reducing the burden of NCDs, improving public health, and enhancing the overall well-being of the population. Notably, researchers from the National Institute for Medical Research (NIMR) have played a significant role in this conference, presenting various topics and engaging in discussions alongside experts from other institutions. Their contributions are valuable in advancing the understanding and management of non-communicable diseases in the region.

Emergence of Artemisinin Partial Resistance in Tanzania: Insights from the 2021 Molecular Surveillance and Implications for Malaria Control A molecular surveillance of malaria in Tanzania (MSMT) survey was conducted in 2021 in 13 regions with different malaria transmission rates. A total of 7,666 samples were collected and analyzed for drug resistance markers. Presenting the study findings during a symposium at American Society of Tropical Medicine and Hygiene (ASTMH) conference 2023 in Chicago, USA, the Principal Investigator, Dr. Deus Ishengoma, reported that k13 561H mutations were detected in Kagera and Tabora regions in 2021. Dr. Ishengoma commented that this raised an alarm of the emergence of artemisinin partial resistance and that artemisinin-based combination therapies (ACTs) efficacy is under threat; and that, the findings prompted a special TES which confirmed artemisinin partial resistance in Tanzania based on WHO criteria. Both drugs had good safety profiles and adequate clinical and parasitological response (ACPR) was above 90%. Furthermore, the Principal Investigator reported that mutations are spreading to other districts and may have potentially reached other regions in the country, and recommended that artemisinin containment strategies are urgently needed in Tanzania Malaria molecular surveillance (MMS) using methods that can screen large sample size are needed to support continued MMS Malaria# Control# #Tanzania

Nimr Molecular Surveillance of Malaria in Tanzania (NMSMT) Project Staff Disseminating Research Findings at ASTMH Conference 2023. At the ASTMH Conference 2023 in Chicago, USA, a total of eight posters showcasing research findings from the MSMT project were presented. These posters were contributed by various individuals, including an intern, an MSc student, three PhD candidates, and three post-doctoral fellows. Congratulations to all the presenters for their valuable contributions. #MSMTProject #MalariaResearch #PublicHealth

Championing Malaria Surveillance: NIMR DG Applauds Progress in the Molecular Surveillance of Malaria in Tanzania (MSMT) Project The National Institute for Medical Research (NIMR) Director General Prof. Said Aboud attended the MSMT project meeting today on 17th October, 2023, which took place in Chicago, USA prior to the start of ASTMH 2023 Conference where MSMT symposium and poster presentations will feature. The meeting was attended by Head of Programs, Dr. Catherine Joachim, National Malaria Control Program (NMCP) Manager, Dr Samuel Lazaro both from MOH, collaborators, BMGF Program Officer, Dr Estee, PI, Dr Deus Ishengoma, NIMR DG and project team members. In his remarks, Prof. Aboud emphasized the significance of malaria as a disease of public health importance in Tanzania and highlighted NIMR close collaboration with the Ministry of Health through NMCT. He commended the uniqueness of the MSMT project, which utilizes Molecular Surveillance approach to monitor malaria in 26 regions of the country and congratulated the excellent progress made so far in the implementation of the project. He acknowledged the financial support provided by the Bill and Melinda Gates Foundation (BMGF) to NIMR through MSMT project. NIMR DG was delighted with immense capacity building of human resources done through training of post-doctoral fellows, PhD, MSc and interns as well as acquisition and establishment of the state-of the art malaria genomics laboratory at NIMR Headquarters. He underscored the importance to ensure that research findings emanating from the project findings should result not only in publications but also policy briefs that can be shared to influence policy change, decision making and best practices in malaria case management, prevention and control in the country. Additionally, Prof. Aboud challenged the project team to develop the much needed MSc in bioinformatics and accredit short course curricula in collaboration with Muhimbili University of Health and Allied Sciences (MUHAS) to offer the trainings with CPD points to individuals in need of the same within and outside the country. Further, he advised project team to prepare action plan to accredit malaria genomics laboratory to increase its reputation internationally. He expressed NIMR commitment to continue collaborating with BMGF and assured of institutional support in ensuring the successful completion of the current phase of the project. #MSMTProject #MalariaResearch #PublicHealth