The five participating institutions from Tanzania (NIMR-Mbeya and Muhimbili University of Allied and Health Sciences), Mozambique (INS/CISPOC in Maputo), Uganda (MRC/UVRI and LSHTM Uganda Research Unit in Masaka) and South Africa (Verulam clinical research site) met in Zanzibar from 15th-17th January 2024. The meeting involved discussions on the recently released Independent Data Monitoring Committee results that required pausing of vaccinations but continued oral PrEP component up to trial completion. Additional discussions were held on planned final trial analyses, plans for unblinding and dissemination of trial results. Discussions were also held on the way forward beyond the PrEPVacc trial for each of the partner sites.